Gut Bacteria May Change Ageing Procedure.
Microorganisms living in the intestine may change the aging process, which might lead to the growth of food-based treatment to slow it down, according to a research.
All organisms, including people , coexist with an assortment of species living on and in them.
Research conducted within the last 20 years has shown the major role intestine microbes play in nourishment, nutrition, metabolism and behavior, as shown by a team led by Nanyang Technological University (NTU) in Singapore.
After eight months, the mice had increased gastrointestinal growth and generation of neurons within the brain.
The analysis, published in the journal Science Translational Medicine, showed that the higher neurogenesis was because of an enrichment of gut microbes which produce a specific short chain fatty acid, known as butyrate.
Butyrate is generated through microbial fermentation of dietary fibres in the lower intestinal tract and also stimulates production of a pro-longevity hormone known as FGF21, which plays a significant part in regulating the body’s energy and metabolism.
Butyrate generation is diminished, as we get older, the researchers stated.
Then they showed that giving butyrate in its own to the youthful germ-free mice had the identical adult neurogenesis effects.
“We’ve discovered that microbes collected in the old mouse have the capacity to encourage neural expansion in a younger mouse,” said Pettersson.
“This is a surprising and very interesting observation, especially since we can mimic the neuro-stimulatory impact by employing butyrate alone,” he said.
The researchers said these results will help explore whether butyrate might support repair and rebuilding in scenarios such as stroke, spinal injury and also to attenuate rapid aging and cognitive decline.
The group also researched the consequences of gut microbe transplants on the works of the system from mice.
On the other hand, the addition of butyrate will help to better regulate the intestinal barrier function and reduce the possibility of inflammation.
The group found that mice receiving microbes out of the older donor gained increases in length and width of the intestinal villi — tiny hair like structures in the walls of the small gut.
Moreover, both colon and the small intestine were more in the mice compared to the youthful germ-free mice.
The discovery indicates that gut microbes support and can compensate an body through stimulation.
This points to a new potential method for tackling the negative effects of aging by copying the enrichment and regeneration of butyrate, the researchers said.
“We could conceive of future human research where we would examine the capability of food products with butyrate to support healthy aging and adult neurogenesis,” said Pettersson.